The white-headed vulture endemic to Africa. Populations have been declining steeply in recent years due to habitat degradation and poisoning of vultures at carcasses. An extinct relative was also present in the Indonesian island of Flores during the Late Pleistocene, indicating that the genus was more widespread in the past.

 A total population of 10,500-18,750 individuals has been estimated, but newer estimates following recent declines suggest a population of just 5,500 individuals. It is estimated that 400 protected areas contain 1893 White-headed vulture nests, with 721 nests occurring in East Africa, 548 in Central Africa, 468 in Southern Africa and 156 in West Africa. The species prefers mixed, dry woodland at low altitudes.

White-headed vulture populations have been declining since the early 1940s; it was classified as Vulnerable in the 2007 IUCN Red List. Recent indications that the species is rarer than previously thought have led to a status upgrade to Critically Endangered in 2015.

The main threats to white-headed vulture populations are reductions in the availability of suitable food sources (carcasses of medium-sized mammals and ungulates) and the loss of habitat to the spread of urban and agricultural developments. Poisoning through baits set for other carnivores such as jackals and hyenas, as well as targeted poisoning of vultures (by poachers who seek to prevent vultures from drawing attention to an illegal kill), is also an important factor. Secondary causes of decline is exploitation for the international trade in raptors and use in traditional medicines.